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Discovery of BBO-8520, a First-in-class Direct and Covalent Dual Inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C

Anna E Maciag, James P Stice, Bin Wang,Alok K Sharma,Albert H Chan, Ken Lin, Devansh Singh,Marcin Dyba, Yue Yang, Saman Setoodeh, Brian P Smith, Jin Hyun Ju, Stevan Jeknic,Dana Rabara, Zuhui Zhang,Erik K Larsen,Dominic Esposito,John-Paul Denson,Michela Ranieri,Mary Meynardie,Sadaf Mehdizadeh, Patrick A Alexander,Maria Abreu Blanco, David M Turner,Rui Xu,Felice C Lightstone,Kwok-Kin Wong,Andrew G Stephen,Keshi Wang,Dhirendra K Simanshu, Kerstin W Sinkevicius,Dwight V Nissley,Eli Wallace,Frank McCormick,Pedro J Beltran

Cancer discovery(2025)

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