Andrew G Stephen - Protein Chemistry Laboratory, National Cancer Institute at Frederick

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Papers共 159 篇Author StatisticsCo-AuthorSimilar Experts

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Biophysical and Structural Analysis of KRAS Switch-Ii Pocket Inhibitors Reveals Allele-Specific Binding Constraints

Patrick Alexander,Albert H Chan,Dana Rabara,Monalisa Swain, Erik K Larsen, Marcin Dyba, Oleg Chertov, Mariam Ashraf, Alison Champagne, Ken Lin,Anna Maciag, William K Gillette,Dwight V Nissley,Frank McCormick,Dhirendra K Simanshu,Andrew G Stephen

The Journal of biological chemistrypp.110331-110331, (2025)

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Blocking C-terminal Processing of KRAS4b Via a Direct Covalent Attack on the CaaX-box Cysteine

Anna E Maciag, Yue Yang,Alok K Sharma, David M Turner,Caroline J DeHart, Hazem Abdelkarim,Lixin Fan, Brian P Smith, Vandana Kumari, Marcin Dyba,Megan Rigby, Jean A Castillo Badillo, Lauren Adams,Luca Fornelli, Stephen Fox, Alla Brafman,Thomas Turbyville,William Gillette, Simon Messing, Constance Agamasu, Andrew L Wolfe,Stephan Gysin,Albert H Chan,Dhirendra K Simanshu,Dominic Esposito, Oleg Chertov,Andrew G Stephen,Michelle Arkin,Adam Renslo, Neil L Kelleher,Vadim Gaponenko,Felice C Lightstone,Dwight V Nissley,Frank McCormick

Proceedings of the National Academy of Sciences of the United States of Americano. 19 (2025): e2410766122-e2410766122

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Discovery of BBO-8520, a First-in-class Direct and Covalent Dual Inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C

Anna E Maciag, James P Stice, Bin Wang,Alok K Sharma,Albert H Chan, Ken Lin, Devansh Singh,Marcin Dyba, Yue Yang, Saman Setoodeh, Brian P Smith, Jin Hyun Ju, Stevan Jeknic,Dana Rabara, Zuhui Zhang,Erik K Larsen,Dominic Esposito,John-Paul Denson,Michela Ranieri,Mary Meynardie,Sadaf Mehdizadeh, Patrick A Alexander,Maria Abreu Blanco, David M Turner,Rui Xu,Felice C Lightstone,Kwok-Kin Wong,Andrew G Stephen,Keshi Wang,Dhirendra K Simanshu, Kerstin W Sinkevicius,Dwight V Nissley,Eli Wallace,Frank McCormick,Pedro J Beltran

Cancer discoveryno. 3 (2025): 578-594

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BBO-10203 Inhibits Tumor Growth Without Inducing Hyperglycemia by Blocking RAS-PI3Kα Interaction

Dhirendra K Simanshu, Rui Xu, James P Stice, Daniel J Czyzyk, Siyu Feng,John-Paul Denson, Erin Riegler, Yue Yang,Cathy Zhang, Sofia Donovan, Brian P Smith, Maria Abreu-Blanco, Ming Chen, Cindy Feng, Lijuan Fu,Dana Rabara, Lucy C Young, Marcin Dyba, Wupeng Yan, Ken Lin, Samar Ghorbanpoorvalukolaie, Erik K Larsen, Wafa Malik, Allison Champagne, Katie Parker, Jin Hyun Ju, Stevan Jeknic,Dominic Esposito, David M Turner,Felice C Lightstone, Bin Wang, Paul M Wehn, Keshi Wang,Andrew G Stephen, Anna E Maciag,Aaron N Hata, Kerstin W Sinkevicius,Dwight V Nissley,Eli M Wallace,Frank McCormick,Pedro J Beltran

Science (New York, NY)pp.eadq2004-eadq2004, (2025)

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Comparative Analysis of KRAS4a and KRAS4b Splice Variants Reveals Distinctive Structural and Functional Properties

Matthew J. Whitley,Timothy H. Tran,Megan Rigby,Ming Yi,Srisathiyanarayanan Dharmaiah,Timothy J. Waybright,Nitya Ramakrishnan,Shelley Perkins,Troy Taylor,Simon Messing,Dominic Esposito,Dwight V. Nissley,Frank McCormick,Andrew G. Stephen,Thomas Turbyville,Gabriel Cornilescu,Dhirendra K. Simanshu

SCIENCE ADVANCESno. 7 (2024)

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Progress in Targeting KRAS Directly

Dwight V Nissley,Andrew G Stephen,Ming Yi,Frank McCormick

Methods in molecular biology（2024）

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Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96

Randa Mahran,Jonas N. Kapp,Salla Valtonen, Allison Champagne,Jinying Ning,William Gillette,Andrew G. Stephen,Feng Hao,Andreas Pluckthun,Harri Harma,Tatu Pantsar,Kari Kopra

ACS CHEMICAL BIOLOGYno. 10 (2024): 2152-2164

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BBO-8520, a First-in-class, Direct Inhibitor of KRASG12C (ON), Locks GTP-bound KRASG12C in the State 1 Conformation Resulting in Rapid and Complete Blockade of Effector Binding

Anna E. Maciag, James Stice, Bin Wang,Alok Sharma,Albert Chan, Ken Lin, Devansh Singh,Marcin Dyba,Yue Yang, Saman Setoodeh, Brian P. Smith,Dana Rabara, Zuhui Zhang,Erik K. Larsen, Dom Esposito,John Paul Denson,Michela Ranieri,Mary Meynardie,Sadaf Mehdizadeh,Patrick Alexander,Maria Abreu Blanco,David Turner,Rui Xu,Felice C. Lightstone,Kwok Kin Wong,Dhirendra Simanshu,Keshi Wang,Andrew G. Stephen,Kerstin Sinkevicius,Dwight V. Nissley,Eli Wallace,Frank McCormick,Pedro J. Beltran

CANCER RESEARCH（2024）

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