Deriving a Health-Based Guidance Value for 9,10-Anthraquinone Via Integrating PBTK Modeling-Based Reverse Dosimetry and in Vitro Bioassays

Da Zhang, Miaoying Shi,Junyu Ning, Shan Zheng, Yi Yang,Xudong Jia, Yaru Tian,Zinan Li,Nan Zhang, Ying Feng,Shan Gao, Zhuangsheng Tan, Jau-Shyong Hong, Ru-Band Lu, Jiaxue Wang,Haiming Jing,Guojun Li

Environment international（2025）

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关键词

9,10-anthraquinone (9,10-AQ),Physiologically based toxicokinetic (PBTK) model,Quantitative in vitro to in vivo extrapolation (QIVIVE),Benchmark dose (BMD),Health-based guidance value (HBGV)

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