Single-cell and Spatial Transcriptomics Reveal a Stress-Induced EMT-like Epithelial Subset Driving Immune Activation in Silica-Injured Lung

Tao Wang, Jianfeng Hao,Bing Li, Ahjol Hyraht, Jialing Wang, Henglei Xia, Qingbin Wu, Wei Gao, Congxia Chen, Chuanqing Yu, Xiuqun Gong, Ting Li, Mei Zhang, Yinghai Xie,Xinrong Tao

Frontiers in immunology（2025）

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Key words

silicosis,alveolar epithelial cells,single-cell RNA sequencing,spatial transcriptomics,epithelial-immune crosstalk

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