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Impaired Glymphatic Function Contributes to High-Frequency Attacks in Patients with Episodic Migraine

Xin Cai, Wei Sun, Mengfei Cai, Dawei Li, Zhenzhen Chen, Hao Li, Bo Yuan, Yan Li, Zaiyi Liu,Yuhu Zhang

The Journal of Headache and Pain(2025)

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Abstract
Previous studies have reported inconsistent results regarding glymphatic function in migraine patients. This study aimed to investigate glymphatic function in patients with episodic migraine (EM), focusing on varying attack frequencies, and to explore its potential pathophysiologic role in migraine. In this cross-sectional study, migraine clinical parameters and psychiatric comorbidities, including depression, anxiety, and sleep disorders, were collected. Three MRI measures were quantified, i.e., the diffusion tensor imaging (DTI) along the perivascular space (DTI-ALPS) index, perivascular space (PVS) volume in the basal ganglia (BG) and white matter (WM), and white matter hyperintensity (WMH) volume in the periventricular WM and deep WM. Patients with 4 or more monthly migraine days (MMDs) were categorized into the high-frequency episodic migraine (HFEM) group, whereas patients with fewer than 4 MMDs were placed in the low-frequency episodic migraine (LFEM) group. The differences in the DTI-ALPS index, PVS volume, and WMH volume were compared between the controls and patients with EM, as well as among the EM subgroups. Correlations between the DTI-ALPS index and migraine clinical parameters, WMH, and PVS were determined. A total of 74 patients with EM without cardiovascular risk factors and 42 age- and sex-matched controls were enrolled. The HFEM group (1.37 ± 0.12) exhibited a significantly lower DTI-ALPS index compared to controls (1.45 ± 0.10; p = 0.011; CI:-0.15 to -0.014) and those with LFEM (1.44 ± 0.12; p = 0.022; CI: -0.14 to -0.008). The reduced DTI-ALPS index was correlated with several clinical parameters, including MMDs, photophobia, phonophobia, and severe headache-related disability. Compared with controls, EM patients presented larger WMH volumes, but no significant differences in PVS volumes were observed. Increased MMDs, long disease duration, the presence of phonophobia, and increased deep WMH volumes were independently associated with the reduced DTI-ALPS index in EM. A reduced DTI-ALPS index, rather than larger PVS volume, may serve as a potential noninvasive measure of compromised glymphatic activity in migraine patients with high-frequency attacks, suggesting potential pathogenic mechanisms for central sensitization. Further longitudinal studies are warranted to investigate the causal relationship between glymphatic function and migraine attacks.
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Key words
Episodic migraine,Glymphatic function,Diffusion tensor imaging,Attack frequency,Hypersensitivity,White matter hyperintensity,Perivascular spaces
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