Targeting Stat3 with Conditional Knockout or PROTAC Technology Alleviates Renal Injury by Limiting Pyroptosis.

Ming-Lu Ji,Jia-Nan Wang, Ming-Fei Wu, Chuan-Hui Xu,Meng-Meng Zhang, Wen-Bao Chang, Xin-Fei Mao, Chao Li, Ju-Tao Yu, Dan-Feng Zhang, Xiao-Guo Suo, Shao-Xi Diao, Nan-Nan Ma,Ying Chen, Rui Hou, Hao Lu, Shuai-Shuai Xie, Yu-Hang Dong, Qi Zhu,Xin Chen, Tao Xu,Wei Shao,Juan Jin, Jia-Gen Wen,Xiao-Wu Dong, Wen-Bin Wang,Jin-Xin Che,Xiao-Ming Meng

EBioMedicine（2025）

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Key words

Stat3,Histone modification,Pyroptosis,Renal injury,PROTAC

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