Development of a Highly Sensitive Luciferase Assay for Intracellular Evaluation of Coronavirus Mpro Activity

Bao Dong, Yuehong Chen, Xin Wang,Jing Li,Sen Zhang,Xiaoping Kang,Yuchang Li, Biao Li, Liangning Liao, Zhengwei Zhang, Jiaqi Xiong, Lele Shao,Shenghai Huang,Ye Feng,Tao Jiang

Frontiers in microbiology（2025）

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Key words

coronavirus,main protease,protease activity,reporter system,NanoBit,protease inhibitor

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