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AMPK Activation Downregulates TXNIP, Rab5, and Rab7 Within Minutes, Thereby Inhibiting the Endocytosis-Mediated Entry of Human Pathogenic Viruses

Viktoria Diesendorf, Veronica La Rocca, Michelle Teutsch, Haisam Alattar,Helena Obernolte, Kornelia Kenst, Jens Seibel, Philipp Wörsdörfer,Katherina Sewald,Maria Steinke,Sibylle Schneider-Schaulies,Manfred B Lutz,Jochen Bodem

Cells(2025)

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Key words
acetylsalicylic acid,salicylic acid,antiviral activity,AMPK,ULK1,eEF2K,eEF2,receptor-mediated endocytosis,RNA viruses,PI3K/mTORC2 pathways,neuronal organoids,precision-cut lung slices
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