SETD2 Loss-of-function Uniquely Sensitizes Cells to Epigenetic Targeting of NSD1-directed H3K36 Methylation

Ryan T. Wagner,Ryan A. Hlady,Xiaoyu Pan,Liguo Wang, Sungho Kim,Xia Zhao,Louis Y. El Khoury, Shafiq Shaikh,Jian Zhong,Jeong-Heon Lee,Jolanta Grembecka,Tomasz Cierpicki, Thai H. Ho,Keith D. Robertson

Genome Biology（2025）

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关键词

Clear cell renal cell carcinoma (ccRCC),SETD2,Histone 3,lysine 36,tri-methylation (H3K36me3),NSD1,Synthetic lethality (SL),CRISPRi,Epithelial-mesenchymal transition (EMT),Homologous recombination (HR),Homology-directed repair (HDR)

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