Multiplexed Sirna Immunoassay Unveils Spatial and Quantitative Dimensions of Sirna Function, Abundance, and Localization in Vitro and in Vivo

Michael Ly, Sandra Diaz-Garcia, Nathaniel Roscoe, Irina Ushach, Zhigang Hong, Monique Franca, Stephanie Schaffer, Tong-Yuan Yang, Mathieu Marella,Glenn Marsboom, Donna Klein, Tamar R. Grossman, Vinicius Carreira, Michael Ollmann

TOXICOLOGIC PATHOLOGY（2025）

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关键词

siRNA: small interfering RNA,GalNAc: N-acetylgalactosamine,PNPDB3 and PNPDB1: siRNA antibodies,HCI: high-content imaging,TMA: tissue microarray,IHC: Immunohistochemistry,IF: Immunofluorescence,CTNNB1: beta-catenin,2' O-Me: 2' O-Methyl,2'-F: 2'-Fluoro,DAPI: 4 ',6-Diamidino-2-phenylindole,PK/PD: Pharmacokinetics and Pharmacodynamics,RT-qPCR: Reverse Transcription Quantitative PCR

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