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Cabozantinib Selectively Induces Proteasomal Degradation of P53 Somatic Mutant Y220C and Impedes Tumor Growth

FangLin Lv,Lu Zhang,Cheng Ji,Lei Peng, Mingxian Zhu, Shumin Yang,Shunli Dong, Mingxuan Zhou, Fanfan Guo,Zhenyun Li, Fang Wang,Youguo Chen,Jinhua Zhou,Xingcong Ren, Genhai Shen,Jin-Ming Yang,Bin Li,Yi Zhang

Journal of Biological Chemistry（2025）

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Key words
cabozantinib,p53Y220C,proteasomal degradation,tumor cells
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