Modeling, Synthesis and Cell-Based Evaluation of Pyridine-Substituted Analogs of CD3254 and Fluorinated Analogs of CBt-PMN As Novel Therapeutics

Peter W. Jurutka, Zainab Khan,Ichiro Kaneko,Michael A. Sausedo,Pritika H. Shahani,Mairi MacNeill,Aleksandra Grozic, Jaskaran Bhogal, Johnathon Sweirski, Michael R. Wentzel, Christine Chhun, Michael T. Applegate,San Raban, Samir Ibrahim, Karar Alwaeli, Tracie L. Feldman, Kayla J. Pomeroy, Joseph T. Sarnowski, Natalia Nguyen,Joseph W. Ziller

Bioorganic & Medicinal Chemistry（2025）

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Key words

Retinoid-X-receptor,Retinoid,Leukemia,Small molecule therapeutic,Structure–activity-relationship

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