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Design and Application of Synthetic 17B-HSD13 Substrates Reveals Preserved Catalytic Activity of Protective Human Variants

Michelle R. Garnsey, Yang Wang,David J. Edmonds, Matthew F. Sammons, Benjamin Reidich,Youngwook Ahn, Yotam Ashkenazi,Anthony Carlo,Matthew A. Cerny,Karen J. Coffman, Jeffrey A. Culver, Anne-Marie Dechert Schmitt,Heather Eng,Ethan L. Fisher,Jemy A. Gutierrez, Larry James, Samantha Jordan,Jeffrey T. Kohrt, Melissa Kramer,Erik A. Lachapelle, Jack C. Lee, Jisun Lee, Dongmei Li, Zhenhong Li,Shenping Liu, Jianhua Liu,Thomas V. Magee, Melissa R. Miller, Michael Moran,Deane M. Nason,Nicole L. Nedoma, Steven V. O'Neil, Mary A. Piotrowski, Jillian Racich,Ruth F. Sommese, Lucy M. Stevens,Ann S. Wright,Jun Xiao, Liying Zhang, Dahui Zhou, Ornella Barrandon,Michelle F. Clasquin

NATURE COMMUNICATIONS(2025)

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