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Genome-wide CRISPR-based Screen Identifies E2F Transcription Factor 1 As a Regulator and Therapeutic Target of Aristolochic Acid-Induced Nephrotoxicity

Ziqi Liu,Huan Gao,Guoliang Li,Yongjiang Yu,Mengxing Cui,Honghao Peng,Xinchao Guan,Xue Zhang, Zhihan Zhang,Xiaoyu Shen,Shen Chen,Daochuan Li,Liping Chen,Yongmei Xiao,Wen Chen,Lili Liu,Qing Wang

ENVIRONMENT INTERNATIONAL（2025）

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Key words
Genome-wide CRISPR screen,AAI,Nephrotoxicity,Apoptosis,CBD
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