Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach

Yam B. Poudel, Julian C. Lo, Derek J. Norris, Matthew Cox,Liqi He,Walter L. Johnson,Murugaiah A. M. Subbaiah, Santigopal Mondal, Soodamani Thangavel,Lakshumanan Subramani, Maheswara Reddy, Suraksha Jain,Dahlia R. Weiss,Prasanna Sivaprakasam,David Critton, Dawn Mulligan,Chunshan Xie, Payal Dhar, Yvonne Li, Emanuela Sega,Sayumi Yamazoe,Ashvinikumar V. Gavai,Arvind Mathur, Christoph W. Zapf, Eugene P. Chekler

ACS MEDICINAL CHEMISTRY LETTERS（2024）

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Key words

TLR7/8 agonist,ADC,cancer,immunomodulatoryconjugate,IMC

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