SARS-CoV-2 S Protein Disrupts the Formation of ISGF3 Complex Through Conserved S2 Subunit to Antagonize Type I Interferon Response.

Zeng Cai,Wenjia Ni, Wenkang Li, Zhixuan Wu, Xiaoqian Yao, Yucheng Zheng,Yongliang Zhao, Weifeng Yuan,Simeng Liang,Qi Wang, Mingliang Tang,Yu Chen,Ke Lan,Li Zhou,Ke Xu

JOURNAL OF VIROLOGY（2025）

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Key words

SARS-CoV-2,spike protein,interferon JAK-STAT pathway,ISGF3 complex,interferon-stimulated gene

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