Determination of the Decapping Efficiency of THIOMAB™ Antibodies with the Engineered Cysteine in the Fc Region for Making Antibody–drug Conjugates by Specific Hinge Fragmentation-Liquid Chromatography

Yun Yang, Jaymin M. Patel, Rong-Sheng Yang, Fengfei Ma, Xiangfeng Niu,Yixiao Zhang, Thomas Niedringhaus, Mohammad Al-Sayah,Xiaoyu Yang

Analytical and Bioanalytical Chemistry（2024）

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关键词

Antibody,mAbs,Thiomabs,Decapping efficiency,Specific hinge fragmentation,Antibody–drug conjugates (ADCs),Engineered cysteine,Fc fragment

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