Integrative Pathway Analysis Across Humans and 3D Cellular Models Identifies the P38 MAPK-MK2 Axis As a Therapeutic Target for Alzheimer’s Disease

Pourya Naderi Yeganeh,Sang Su Kwak,Mehdi Jorfi,Katjusa Koler, Thejesh Kalatturu,Djuna von Maydell, Zhiqing Liu, Kevin Guo,Younjung Choi,Joseph Park, Nelson Abarca,Grisilda Bakiasi,Murat Cetinbas,Ruslan Sadreyev,Ana Griciuc,Luisa Quinti,Se Hoon Choi,Weiming Xia,Rudolph E. Tanzi,Winston Hide,Doo Yeon Kim

NEURON（2025）

引用 0|浏览1

关键词

Alzheimer’s disease,drug target discovery,tau pathology,3D human neuronal cell models,transcriptomics,phosphoproteomics,integrative analysis,pathway analysis,p38 MAP kinase,amyloid beta 42

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要