Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 As Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents

Rebecca Vairin,Caleb Tamminga,Zhe Shi, Christian Borchardt, Jayaram Jambulapati,Ruoli Bai,Hashini Wanniarachchi, Lorena Bueno,Ernest Hamel,Ralph P. Mason,Mary Lynn Trawick,Kevin G. Pinney

BIOORGANIC & MEDICINAL CHEMISTRY（2025）

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关键词

Inhibitors of tubulin polymerization,Antiproliferative agents,Colchicine binding site,Vascular disrupting agents,Indole synthesis,Molecular docking,Anticancer therapeutic agents

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