Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells
Mélanie Uguen,Devan J Shell, Madhushika Silva,Yu Deng,Fengling Li,Magdalena M Szewczyk,Ka Yang, Yani Zhao,Michael A Stashko,Jacqueline L Norris-Drouin,Jarod M Waybright,Serap Beldar,Justin M Rectenwald,Angie L Mordant, Thomas S Webb,Laura E Herring,Cheryl H Arrowsmith,Suzanne Ackloo,Steven P Gygi,Robert K McGinty,Dalia Barsyte-Lovejoy,Pengda Liu,Levon Halabelian,Lindsey I James,Kenneth H Pearce,Stephen V Frye Nature communications(2025)
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