PF-06952229, a Selective TGF-β-R1 Inhibitor: Preclinical Development and a First-in-human, Phase I, Dose-Escalation Study in Advanced Solid Tumors

T. A. Yap,A. D. Choudhury,E. Hamilton, L. S. Rosen, K. L. Stratton, M. S. Gordon, D. Schaer, L. Liu, L. Zhang, R. K. Mittapalli, W. Zhong, N. Soman,A. W. Tolcher

ESMO OPEN（2024）

Cited 2|Views5

Key words

TGF-beta-R1 inhibitor,advanced solid tumors,TGF-beta signaling,epithelial-mesenchymal transition,metastatic castration-resistant prostate cancer

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