Identification of USP2 As a Novel Target to Induce Degradation of KRAS in Myeloma Cells

Yingying Wang,Youping Zhang,Hao Luo, Wei,Wanting Liu,Weiwei Wang,Yunzhao Wu, Cheng Peng,Yanjie Ji, Jianfang Zhang, Chujiao Zhu, Wenhui Bai,Li Xia,Hu Lei,Hanzhang Xu, Leimiao Yin, Wei Weng,Li Yang,Ligen Liu,Aiwu Zhou, Yueyue Wei, Qi Zhu, Weiliang Zhu, Yongqing Yang, Zhijian Xu,Yingli Wu

ACTA PHARMACEUTICA SINICA B（2024）

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关键词

Ubiquitin-specific protease 2,KRAS,Gambogic acid,Multiple myeloma,Degradation,Ubiquitination,Allosteric pocket,Deubiquitination

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