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Microsatellite Instability at U2AF-binding Polypyrimidic Tract Sites Perturbs Alternative Splicing During Colorectal Cancer Initiation

Vincent Jonchère, Hugo Montémont, Enora Le Scanf,Aurélie Siret,Quentin Letourneur,Emmanuel Tubacher,Christophe Battail, Assane Fall,Karim Labreche,Victor Renault,Toky Ratovomanana,Olivier Buhard,Ariane Jolly,Philippe Le Rouzic, Cody Feys,Emmanuelle Despras,Habib Zouali,Rémy Nicolle,Pascale Cervera,Magali Svrcek,Pierre Bourgoin,Hélène Blanché,Anne Boland,Jérémie Lefèvre,Yann Parc,Mehdi Touat,Franck Bielle,Danielle Arzur,Gwennina Cueff,Catherine Le Jossic-Corcos, Gaël Quéré,Gwendal Dujardin,Marc Blondel,Cédric Le Maréchal,Romain Cohen,Thierry André,Florence Coulet,Pierre de la Grange,Aurélien de Reyniès,Jean-François Fléjou,Florence Renaud,Agusti Alentorn,Laurent Corcos,Jean-François Deleuze,Ada Collura,Alex Duval

GENOME BIOLOGY（2024）

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关键词
Colorectal cancer,Mismatch repair deficiency,Microsatellite instability,Whole-exome and RNA sequencing,Alternative splicing,Polypyrimidine U2AF binding site,Colonic crypt,Cancer initiation,Cell differentiation
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