Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor

Darragh P. O'Brien,Hannah B. L. Jones, Yuqi Shi,Franziska Guenther,Iolanda Vendrell,Rosa Viner,Paul E. Brennan,Emma Mead,Tryfon Zarganes-Tzitzikas,John B. Davis,Adan Pinto-Fernandez,Katherine S. England,Emma J. Murphy,Andrew P. Turnbull,Benedikt M. Kessler

JOURNAL OF PROTEOME RESEARCH（2025）

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Key words

mitophagy,ubiquitin specific protease USP30,cyanopyrrolidine inhibitors,activity-based protein profilingmass spectrometry,enzyme kinetics,Hydrogen-DeuteriumeXchange-Mass spectrometry,molecular docking

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