WeChat Mini Program
Old Version Features

Dual-emission Carbon Dots-Based Biosensor for Polarity/targeting Bimodal Recognition and Mild Photothermal Therapy of Tumor

Talanta(2025)SCI 2区

Shanxi Univ

Cited 0|Views6
Abstract
It is essential to develop a multifunctional nanoplatform for biosensing, tumor diagnosis and treatment simultaneously. Herein, dual-emission fluorescent carbon dots (HA-CDs) were fabricated via a one-pot solvothermal method using spinach powder as carbon source and hyaluronic acid (HA) as targeting agent. The obtained HA-CDs exhibited outstanding optical properties, good targeted tumor and excellent photothermal conversion performance. Interestingly, HA-CDs can sensitively perceive the changes in polar environments attributed to the inherent ratiometric fluorescence characteristics, and combined with the intrinsic targeting tumor ability achieved tumor cell recognition. More importantly, the HA-CDs possess good photothermal conversion efficiency of 21.2 % to be beneficial for photothermal therapy of tumors. The survival rate of HeLa cells incubated with HA-CDs dramatically decreased to 14 % after 660 nm laser irradiation, revealing the significant tumor inhibition of HA-CDs in vitro. Notably, through individual intraperitoneal and intratumoral injection, it was found that HA-CDs demonstrated a similar tumor suppressed effect on 4T1 tumor-bearing mice exposed to laser irradiation, fully uncovering that HA-CDs can efficiently accumulate at tumor site by intraperitoneal injection. Besides, the histopathological analysis of major organs ex vivo revealed a good biosafety profile. Collectively, this strategy of designed HA-CDs provides a new multifunctional nanoplatform for potential clinical application.
More
Translated text
Key words
Carbon dots,Dual-emission fluorescent,Polarity,Tumor-target,Tumor cells recognition,Photothermal therapy
求助PDF
上传PDF
Bibtex
AI Read Science
AI Summary
AI Summary is the key point extracted automatically understanding the full text of the paper, including the background, methods, results, conclusions, icons and other key content, so that you can get the outline of the paper at a glance.
Example
Background
Key content
Introduction
Methods
Results
Related work
Fund
Key content
  • Pretraining has recently greatly promoted the development of natural language processing (NLP)
  • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
  • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
  • The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
  • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
Upload PDF to Generate Summary
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Related Papers
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn
Chat Paper

要点】:本文提出了一种双发射荧光碳点(HA-CDs)的生物传感器,用于肿瘤的极性/靶向双模识别和温和光热治疗,具有优异的光学性能、良好的肿瘤靶向性和光热转换效率。

方法】:通过一锅法溶剂热方法,使用菠菜粉作为碳源,透明质酸(HA)作为靶向剂,制备了双发射荧光碳点。

实验】:在660 nm激光照射下,与HA-CDs孵育的HeLa细胞存活率显著降至14%,体内实验中使用4T1肿瘤小鼠模型,通过腹腔和肿瘤内注射,发现HA-CDs在激光照射下对肿瘤有显著的抑制效果,且体内主要器官的病理分析显示良好的生物安全性。实验使用的数据集为HeLa细胞和4T1肿瘤小鼠模型。