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Design, Synthesis and Antitumor Activity of a Novel FGFR2-selective Degrader to Overcome Resistance of the FGFR2V564F Gatekeeper Mutation Based on a Pan-Fgfr Inhibitor

Zuli Hu,Qiangsheng Zhang, Zulong Li,Hongling Yang, Xin Chen,Qi Zhang, Tianqiong Yang,Xiaojie He,Qiang Feng,Jun He,Luoting Yu

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（2024）

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关键词
FGFR2,PROTAC,Gatekeeper mutation,Antitumor agents
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