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    • 881-P: Optimizing Glycemic Control in Type 2 Diabetes Using Novel Endoscopic Pulsed Electric Field Therapy—A Study of Outcomes and Predictive Factors

    BARHAM K. ABU DAYYEH,ADRIAN SARTORETTO,ANDREW C. STORM, HOWARD M. MCCOLLISTER,PAUL A. SEVERSON,BRONTE HOLT,GEORGINA CAMERON,RHYS VAUGHAN,JOHN LIPHAM, ELIF I. EKINCI, DAVID N. O'NEAL

    Diabetes（2024）

    Cited 0|Views3
    Abstract
    Background: Duodenal dysfunction, specifically in nutrient sensing, iron homeostasis, and inflammation is linked to Type 2 Diabetes. This study assesses Endoscopic Re-Cellularization via Electroporation Therapy (ReCET™), an outpatient procedure using non-thermal pulsed electric field to regenerate the duodenal function. Methods: Participants (18-70 years, BMI 24-40 kg/m², HbA1c 7.5%-11.0%, on 1-4 non-insulin antidiabetics) received PEF. Primary endpoints were serious adverse events at 12 weeks, with secondary endpoints including efficacy and response predictors at 24 weeks. Results: 71 patients (age 55, 73% male, BMI 31.7 kg/m², T2D duration 5.8 years, baseline HbA1c 8.6%) participated. Treatment groups received either low or high energy doses. No SAEs occurred. The high energy group exhibited significant glycemic improvement (-1.11 HbA1c reduction vs. -0.32 in low energy group, p=0.015) and improved Time in Range, %TBWL, HOMA-IR, Triglyceride, and Ferritin. Baseline Ferritin and HbA1c were predictors of response (figure 1). Subgroup with baseline Ferritin ≥200 and HbA1c ≥8 showed a -2.04 [95%CI -3.94, -0.14] HbA1c reduction at 24 weeks with high energy. Conclusions: ReCET™ enhances glycemic control in T2D without SAEs, impacting weight, lipid profile, and iron metabolism. This suggests a novel mechanism complementing existing T2D treatments. B.K. Abu Dayyeh: Research Support; USGI Medical, Apollo Endosurgery. Consultant; Boston Scientific Corporation, Medtronic. Other Relationship; Endogenex. Research Support; ERBE. A. Sartoretto: Research Support; Endogenex, Erbe Electromedizin GmbH. Advisory Panel; Bariatek. Consultant; Boston Scientific Corporation, Intuitive Surgical. A.C. Storm: Consultant; Intuitive Surgical, Boston Scientific Corporation, Olympus. Research Support; Apollo Endosurgery, Endogenex, Microtech. Consultant; Enterasense. Research Support; OnePass. H.M. McCollister: Consultant; Endogenex. P.A. Severson: Consultant; Endogenex. B. Holt: None. G. Cameron: None. R. Vaughan: None. J. Lipham: Consultant; Endogenex, Ethicon, Inc., Implantica. E.I. Ekinci: Advisory Panel; Lilly Diabetes. Research Support; Novo Nordisk, Boehringer-Ingelheim, Eli Lilly and Company. Board Member; Eli Lilly and Company. Advisory Panel; Abbott. Research Support; Endogenex, Versanis, AstraZeneca. D.N. O'Neal: None.
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