Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. David J. Hirst , Paul Bamborough , Niam Al-Mahdi , Davina C. Angell , Heather A. Barnett , Andrew Baxter , Rino A. Bit , Jack A. Brown , Chun-wa Chung , Peter D. Craggs , Robert P. Davis , Emmanuel H. Demont , Alan Ferrie , Laurie J. Gordon , Isobel Harada , Tim C. T. Ho , Ian D. Holyer , Edward Hooper-Greenhill , Katherine L. Jones , Matthew J. Lindon , Cerys Lovatt , David Lugo , Claire Maller , Grant Mcgonagle , Cassie Messenger , Darren J. Mitchell , David D. Pascoe , Vipulkumar K. Patel , Christopher Patten , Darren L. Poole , Rishi R. Shah , Inmaculada Rioja , Kayleigh A. J. Stafford , Daniel Tape , Simon Taylor , Natalie H. Theodoulou , Laura Tomlinson , Ian D. Wall , Christopher R. Wellaway , Gemma White , Rab K. Prinjha , Philip G. Humphreys JOURNAL OF MEDICINAL CHEMISTRY（2024）
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