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Molecular Glue Triggers Degradation of PHGDH by Enhancing the Interaction Between DDB1 and PHGDH

Ziqi Huang,Kun Zhang,Yurui Jiang, Mengmeng Wang, Mei Li,Yuda Guo, Ruolin Gao, Ning Li, Chenyang Wang,Jia Chen,Jiefu Wang,Ning Liu,Xiang Liu,Shuangwei Liu,Mingming Wei,Cheng Yang,Guang Yang

Acta Pharmaceutica Sinica B（2024）

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关键词
Molecular glue,Targeted protein degradation,PHGDH,Cancer stem cells,PROTACs
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