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Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride That Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain

Seth C. Hopkins, Siriporn Toongsuwan,Taryn J. Corriveau,Takao Watanabe, Yuki Tsushima, Takumi Asada,Robert Lew, Lei Shi,Vanessa Zann,Thomas J. Snowden,Piet H. van Der Graaf,Borje Darpo,Graham E. Searle,Eugenii A. Rabiner, Ian Wilding,Steven T. Szabo,Gerald R. Galluppi,Kenneth S. Koblan

Clinical Pharmacology & Therapeutics（2024）

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