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Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study

Sudeshna Das,Yao Ge,Yuting Guo,Swati Rajwal, Jamor Hairston,Jeanne Powell,Drew Walker,Snigdha Peddireddy,Sahithi Lakamana, Selen Bozkurt,Matthew Reyna,Reza Sameni,Yunyu Xiao,Sangmi Kim,Rasheeta Chandler,Natalie Hernandez,Danielle Mowery,Rachel Wightman,Jennifer Love,Anthony Spadaro,Jeanmarie Perrone,Abeed Sarker

JOURNAL OF MEDICAL INTERNET RESEARCH（2025）

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Key words
retrieval-augmented generation,substance use,social media,large language models,natural language processing,artificial intelligence,GPT,psychoactive substance
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