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Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding

Jun Liang,Michael J. Lambrecht,Teresita L. Arenzana,Samuel Aubert-Nicol,Linda Bao,Fabio Broccatelli, Jianping Cai,Celine Eidenschenk,Christine Everett, Thomas Garner,Felix Gruber,Pouyan Haghshenas,Malcolm P. Huestis,Peter L. Hsu,Ponien Kou,Araz Jakalian,Robin Larouche-Gauthier,Jean-Philippe Leclerc,Dennis H. Leung, Aaron Martin,Jeremy Murray, Madeleine Prangley,Sascha Rutz,Satoko Kakiuchi-Kiyota,Alexander Lee Satz,Nicholas J. Skelton,Micah Steffek, Daniel Stoffler,Jawahar Sudhamsu, Sophia Tan,Jian Wang, Shouliang Wang, Qiuyue Wang,Timothy J. Wendorff,Moreno Wichert,Arun Yadav,Christine Yu,Xiaojing Wang

ACS Medicinal Chemistry Letters（2024）

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Key words
Cancer Immunotherapy,Cbl-b,Druggability,DEL,SH2,Structure-BasedDesign,RING E3 ligase,Protein-Protein Interaction
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