Insights into the Selective Anticancer Activity of [sniv(l)(cl)2(oh2)] [L =(E)-N,n-diethyl-2-(2-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide] at Thiosemicarbazone Appended Tin(iv) Site
Inorganic Chemistry Communications（2024）
Univ Burdwan
Abstract
We herein report the synthesis of a mononuclear tin(IV) complex [SnIV(L)(Cl)2(OH2)] [L = (E)-N,N-diethyl-2-(2-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide] (1). From the X-ray crystallographic characterization the molecular geometry of 1 around Sn(IV) center has been found to be distorted octahedron. The present report illustrates the selective reactivity of 1 against human lung carcinoma epithelial cell line, A549 by inducing depolarization of the mitochondrial membrane potential resulting in selective cancer cell death.
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Key words
Sn(IV),Thiosemicarbazone,X-ray structure,Anticancer activity
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