Increased Levels of GM-CSF and CXCL10 and Low CD8+ Memory Stem T Cell Count Are Markers of Immunosenescence and Severe COVID-19 in Older People

Johanne Poisson,Carine El-Sissy,Arnaud Serret-Larmande,Nikaïa Smith, Morgane Lebraud,Jean-Loup Augy,Catherine Conti,Cécile Gonnin,Benjamin Planquette,Jean-Benoît Arlet,Bertrand Hermann,Bruno Charbit,Jean Pastre, Floriane Devaux, Cyrielle Ladavière, Lydie Lim, Pauline Ober, Johanna Cannovas,Lucie Biard, Marie-Christelle Gulczynski, Noémie Blumenthal,Hélène Péré,Camille Knosp,Alain Gey,Nadine Benhamouda,Juliette Murris,David Veyer,Eric Tartour,Jean-Luc Diehl,Darragh Duffy,Elena Paillaud,Clémence Granier

Immunity & Ageing（2024）

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关键词

Immunosenescence,Inflammaging,Immune-ageing,COVID-19,Geriatrics,Infections,Senescence-associated secretory phenotype,CD8-positive T-lymphocytes,GMCSF,CXCL10,TSCM

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