The Full Spectrum of SLC22 OCT1 Mutations Illuminates the Bridge Between Drug Transporter Biophysics and Pharmacogenomics

Sook Wah Yee,Christian B. Macdonald,Darko Mitrovic,Xujia Zhou,Megan L. Koleske,Jia Yang,Dina Buitrago Silva,Patrick Rockefeller Grimes,Donovan D. Trinidad,Swati S. More,Linda Kachuri,John S. Witte,Lucie Delemotte,Kathleen M. Giacomini,Willow Coyote-Maestas

Molecular Cell（2024）

Cited 3|Views24

Key words

drug transporter,structure prediction,pharmacogenomics,structure-function,deep mutational scanning,membrane protein folding,precision medicine,OCT1,SLC22

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