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Cryo-EM Analysis of Complement C3 Reveals a Reversible Major Opening of the Macroglobulin Ring

Trine Amalie Fogh Gadeberg, Martin Høgholm Jørgensen,Heidi Gytz Olesen,Josefine Lorentzen,Seandean Lykke Harwood, Ana Viana Almeida, Marlene Uglebjerg Fruergaard,Rasmus Kjeldsen Jensen,Philipp Kanis,Henrik Pedersen, Emil Tranchant,Steen Vang Petersen, Ida Buch Thøgersen,Birthe Brandt Kragelund, Joseph Anthony Lyons,Jan Johannes Enghild,Gregers Rom Andersen

Nature Structural & Molecular Biology（2025）

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