Accumulation of APP C-terminal Fragments Causes Endolysosomal Dysfunction Through the Dysregulation of Late Endosome to Lysosome-Er Contact Sites

Marine Bretou,Ragna Sannerud,Abril Escamilla-Ayala, Tom Leroy,Celine Vrancx,Zoe P. Van Acker,Anika Perdok,Wendy Vermeire,Inge Vorsters, Sophie Van Keymolen,Michelle Maxson,Benjamin Pavie,Keimpe Wierda,Eeva-Liisa Eskelinen,Wim Annaert

DEVELOPMENTAL CELL（2024）

Cited 5|Views20

Key words

presenilins,γ-secretase,lysosomal Ca2+,endolysosomal homeostasis,late endosome/lysosome-endoplasmic reticulum contact sites,APP proteolysis,APP-CTF,primary hippocampal neurons,γ-secretase inhibitor

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