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Cryo-EM Structures Reveal Two Allosteric Inhibition Modes of PI3KαH1047R Involving a Re-Shaping of the Activation Loop

Xiuliang Huang, Kailiang Wang, Jing Han, Xiumei Chen, Zhenglin Wang, Tianlun Wu, Bo Yu, Feng Zhao,Xinjuan Wang,Huijuan Li,Zhi Xie,Xiaotian Zhu,Wenge Zhong, Xiaoming Ren

Structure（2024）

Cited 1|Views125
Key words
PI3KαH1047R,allosteric inhibitor,cryo-EM,activation loop,drug discovery,breast cancer
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