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Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497

Christopher P. Ashcroft, Alexander M. Berne, Florian Blasberg, Kelly Catlin,Michael R. Collins, Doug J. Critcher,Jean-Nicolas Desrosiers,Adam Goetz,Cheryl Hayward, Ricky A. Jones,Michael J. Karmilowicz,Nandell Keene,Carlos A. Martinez,Sebastien Monfette, Sebastian David Pattavina,Hahdi H. Perfect,John A. Ragan, Blake Rauschenberger,Neal W. Sach, Gemma Scotney,Scott C. Sutton, Courtney Talicska,Steven J. R. Twiddle, Jared Van Haitsma, Richard Wisdom

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2024）

Cited 1|Views24

Key words

Oxetane,Biocatalysis,Process Chemistry,Scale-up,EZH2,API

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