A Biomarker-Stratified Comparison of Top-Down Versus Accelerated Step-Up Treatment Strategies for Patients with Newly Diagnosed Crohn's Disease (PROFILE): a Multicentre, Open-Label Randomised Controlled Trial Nurulamin M. Noor , James C. Lee , Simon Bond , Francis Dowling , Biljana Brezina , Kamal Patel , Tariq Ahmad , Paul J. Banim , James W. Berrill , Rachel Cooney , Juan De La Revilla Negro , Shanika de Silva , Shahida Din , Dharmaraj Durai , John N. Gordon , Peter M. Irving , Matthew Johnson , Alexandra J. Kent , Klaartje B. Kok , Gordon W. Moran , Craig Mowat , Pritash Patel , Chris S. Probert , Tim Raine , Rebecca Saich , Abigail Seward , Dan Sharpstone , Melissa A. Smith , Sreedhar Subramanian , Sara S. Upponi , Alan Wiles , Horace R. T. Williams , Gijs R. van den Brink , Severine Vermeire , Vipul Jairath , Geert R. D'Haens , Eoin F. McKinney , Paul A. Lyons , James Lindsay , Nicholas A. Kennedy , Kenneth G. C. Smith , Miles Parkes LANCET GASTROENTEROLOGY & HEPATOLOGY（2024）
Key words
Treatment, Diagnosis
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