Evolution of the Synthetic Process to an Advanced GPR40 Agonist

Xiaoping Hou,Lucas W. Hernandez,Elizabeth A. Jurica,Rulin Zhao, Bei Wang,Michael Wong,Jung-Hui Sun,Dawn Sun,Dauh-Rurng Wu,Changxia Yuan,Michael Hay, Miao Yu,Ximao Wu, Yanting Huang,Bruce A. Ellsworth,Francisco Gonzalez Bobes,Arvind Mathur,James Kempson

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2024）

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GPR40,asymmetric aldolformation,(Z)-olefin,Lindlarhydrogenation,O-alkylation,processoptimization,Andoolefination,lithium diisobutyl-t-butoxyaluminumhydride (LDBBA)

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