上尿路结石成分与循环维生素水平的相关性研究
International Journal of Urology and Nephrology（2023）
上海交通大学医学院附属新华医院
Abstract
目的 探讨上尿路结石患者的血浆维生素水平与结石成分的关系.方法 选取2020年1月至2021年8月在本院收治的上尿路结石患者(结石组,320例)和同期非尿路结石患者(对照组,90例)的临床资料,再将结石组分为感染性结石组(80例)和非感染性结石组(240例),并将结石组患者按结石成分分为磷酸盐结石组(162例)、草酸盐结石组(106例)、尿酸盐结石(29例)和碳酸钙结石组(20例)、磷酸镁铵(2例)和胱氨酸结石(1例).记录所有患者的血浆维生素水平,同时收集并分析患者术后的结石成分,分析两组的维生素水平差异和引起上尿路结石的相关影响因素.结果 结石组中占比最大的是磷酸钙结石,其次是草酸钙结石,占比最小的是胱氨酸结石.结石组和对照组患者的血浆维生素A、维生素B1(2、6、9、12)、维生素C、维生素D及维生素E水平比较,差异均无统计学意义(均P＞0.05).感染性结石组和非感染性结石组的上述血浆维生素水平比较,差异均无统计学意义(均P＞0.05).与对照组相比,磷酸盐、草酸盐、尿酸盐和碳酸钙结石组患者中的血浆维生素B2(6、12)、维生素C、维生素D及维生素E比较,差异均无统计学意义(均P＞0.05),但维生素B1、维生素B9、维生素A比较,差异均有统计学意义(均P＜0.05).碳酸钙结石组患者的血浆维生素A较其他组升高,差异均有统计学意义(均P＜0.05).尿酸结石组中的维生素B1、维生素B9水平低于草酸钙结石组、磷酸钙结石组,差异均有统计学意义(均P＜0.05).结石组的血尿酸水平高于对照组(P＜0.05),尿酸结石组的血尿酸升高最明显.维生素B1与血尿酸水平存在相关性(r=-0.878,P＜0.05).结论 碳酸钙结石患者的血浆维生素A升高,尿酸结石患者的血浆维生素B1、维生素B9降低,调整患者维生素水平可能有助于降低特定结石的形成风险.
MoreKey words
Urinary Calculi,Vitamins,Uric Acid,Calcium Oxalate
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