Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists

Christopher G. Thomson, Kelly Boss, Amy Calhoun,Cary Fridrich,Kevin M. Gardinier, Edward C. Hall,Keith Jendza,Louise Kirman,Nancy Labbe-Giguere,Kurt Laumen, Ming Qian, Sanjit Sanyal,Michael D. Shultz,Radka Snajdrova,Kian Tan, Kate Yaping Wang, Fan Yang,Feng Gao, Tao Hong, Elena Dale, Brent Kuzmiski, Danny Ortuno,Daniel S. Palacios

ACS MEDICINAL CHEMISTRY LETTERS（2023）

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关键词

selective CHRM4 agonist,biocatalysis,asymmetricsynthesis,muscarinic receptors,bifunctional aminebuilding blocks,aminotransferase

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