Deep Mutational Scanning of CYP2C19 in Human Cells Reveals a Substrate Specificity-Abundance Tradeoff
Gabriel E. Boyle,Katherine A. Sitko,Jared G. Galloway,Hugh K. Haddox,Aisha Haley Bianchi, Ajeya Dixon, Melinda K. Wheelock, Allyssa J. Vandi, Ziyu R. Wang,Raine E. S. Thomson,Riddhiman K. Garge,Allan E. Rettie,Alan F. Rubin,Renee C. Geck,Elizabeth M. J. Gillam,William S. Dewitt,Frederick A. Matsen,Douglas M. Fowler GENETICS（2024）
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deep mutational scanning,cytochrome P450,substrate specificity,thermodynamic stability
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