Sebaceous Gland Reprogramming with a Single Gene, PPARG, and Small Molecules
Signal Transduction and Targeted Therapy(2023)
Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department and 4th Medical Center
Abstract
Dear Editor, Sebaceous glands(SG)contribute to 90%of the skin surface lipid production and play critical roles in regulating proper skin functions including epidermal barrier maintenance,dermal immune responses,and global body anti-microbial activities.1 Reduced sebaceous lipid has been implicated in diverse skin diseases,including scarring alopecia,inflammation,chronic itch,as well as premature aging of the skin.2 Especially,scar repair after deep burns or large-scale skin defect often leads to irreversible loss of appendages.
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Key words
Reprogramming,Skin stem cells,Medicine/Public Health,general,Internal Medicine,Cancer Research,Cell Biology,Pathology,Oncology
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