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Discovering Selective Antiferroptotic Inhibitors of the 15LOX/PEBP1 Complex Noninterfering with Biosynthesis of Lipid Mediators.

Haider H. Dar,Karolina Mikulska- Ruminska,Yulia Y. Tyurina,Diane K. Luci,Adam Yasgar,Svetlana N. Samovich,Alexander A. Kapralov,Austin B. Souryavong,Vladimir A. Tyurin,Andrew A. Amoscato,Michael W. Epperly,Galina V. Shurin,Melissa Standley,Theodore R. Holman,Claudette M. St. Croix,Simon C. Watkins,Andrew P. VanDemark,Sandeep Rana,Alexey V. Zakharov,Anton Simeonov,Juan Marugan,Rama K. Mallampalli,Sally E. Wenzel,Joel S. Greenberger,Ganesha Rai,Huelya Bayir,Ivet Bahar,Valerian E. Kagan

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA（2023）

Cited 12|Views61
Key words
ferroptosis,lipid peroxidation,15-lipoxygenase,inhibitor design,PEBP1
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