Phage-Assisted, Active Site-Directed Ligand Evolution with a Genetically EncodedN^ε-Butyryl-L-Lysine to Identify a Cellularly Potent and Selective Inhibitor for the ENL YEATS Domain as an Anti-Leukemia Agent

bioRxiv (Cold Spring Harbor Laboratory)（2023）

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selective inhibitor,ligand,enl yeats domain,phage-assisted,site-directed,butyryl-l-lysine,anti-leukemia

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Phage-Assisted, Active Site-Directed Ligand Evolution with a Genetically EncodedNε-Butyryl-L-Lysine to Identify a Cellularly Potent and Selective Inhibitor for the ENL YEATS Domain as an Anti-Leukemia Agent