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Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib

Yonggang Chen,Luca Iuzzolino,Samantha A. Burgess,Cheol K. Chung,James Corry, Morgan Crawford,Richard Desmond,Erik Guetschow,Clara Hartmanshenn,Nadine Kuhl, Zhu Liu,Hanlin Luo, Alison C. McQuilken,Justin A. Newman,Hong Ren,David A. Thaisrivongs,Zhixun Wang,Eric Sirota

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2023）

Cited 7|Views22
Key words
SNAr,API,synergistic solubility,polish filtration,BTK inhibitor,crystallization,impurity crystallization kinetics
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