当归饮子联合卡泊三醇软膏治疗血燥型银屑病的临床疗效及对免疫炎性因子的影响
Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine（2023）
Abstract
目的 观察当归饮子联合卡泊三醇软膏对血燥型银屑病患者的临床疗效.方法 选取就诊于中日友好医院诊断为血燥型银屑病患者60例,将患者随机分为观察组和对照组各30例.对照组皮损处外用卡泊三醇软膏,观察组在对照组的基础上加用当归饮子,2组均治疗8周,8周后观察患者银屑病皮损面积及严重程度指数(PASI)、体表面积(BSA)、皮肤病生活质量指数(DLQI)及中医证候评分的变化;同时检测2组患者治疗前后血清中干扰素-γ(IFN-γ)、白细胞介素-17A(IL-17A)和IL-10的表达水平.结果 治疗8周后,2组PASI、BSA、DLQI评分均较治疗前显著降低(P<0.05),且观察组显著低于对照组(P<0.05),观察组总有效率(90.0％,27/30)显著高于对照组(70.0％,21/30,P<0.05);2组皮肤瘙痒、皮肤干燥、口干、便干等中医证候均较前降低(P<0.05),其中观察组皮肤瘙痒、皮肤干燥、口干改善更为明显(P<0.05).2组外周血IFN-γ、IL-17A的表达水平显著下降,IL-10的表达水平显著升高(P<0.05),其中观察组外周血IFN-γ、IL-17A的表达水平较对照组降低更为显著(P<0.05).结论 当归饮子联合卡泊三醇软膏治疗血燥型银屑病较单用卡泊三醇软膏能显著改善患者皮损严重程度、皮肤瘙痒干燥等临床表现以及免疫炎性反应相关指标,提高患者生活质量,值得临床推广应用以及进一步深入探究.
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