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Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: from Discovery Synthesis to First Kilogram-Scale Manufacture

Aaron Baldwin,Shawn Cabral,Kris N. Jones,Jeffrey T. Kohrt,Chris Limberakis,Yiyang Liu,Javier Magano,Sebastien Monfette,Asaad Nematalla, Sami Ovaska,David W. Piotrowski,Jared L. Piper,Jeffrey W. Raggon,Benjamin A. Thuma,Liuqing Wei

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2023）

引用 2|浏览17

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Pfitzinger reaction,C-O coupling,alkylation,PF-07059013,HbS modulator

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